Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28071819 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL399572 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL7088576 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL12952342 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL4938419 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL6981275 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL4938867 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL13282093 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| SCHEMBL3779843 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RAB9APOLBTDP1 | |
| Hydrochloric Acid SCHEMBL31029934 | 0.98 | ALDH1A1 (0.50) | ALDH1A1CYP2C19RAB9APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834568-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| EP-1960372-B1 | KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-12-09 | — | — | EP | disclosed |