Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650362 | 0.85 | ENPP1 (0.55) | ENPP1AURKBKDRAURKAEGFR | |
| SCHEMBL12431119 | 0.85 | ENPP1 (0.55) | ENPP1AURKBKDRAURKAEGFR | |
| SCHEMBL16760411 | 0.84 | ENPP1 (0.68) | ENPP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL16685032 | 0.79 | ENPP1 (0.68) | ENPP1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL20865224 | 0.79 | ENPP1 (0.45) | ENPP1AURKBHDAC6AURKAEGFR | |
| SCHEMBL1010156 | 0.78 | ENPP1 (0.79) | ENPP1KDREGFR | |
| SCHEMBL1011724 | 0.78 | ENPP1 (0.79) | ENPP1KDREGFR | |
| SCHEMBL30053845 | 0.78 | ENPP1 (0.79) | ENPP1KDREGFR | |
| SCHEMBL295891 | 0.78 | ENPP1 (0.68) | ENPP1IRAK4KDREGFR | |
| SCHEMBL297514 | 0.78 | ENPP1 (0.68) | ENPP1IRAK4KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |