Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 10/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12431119 | 1.00 | ENPP1 (0.55) | ENPP1AURKAAURKBEGFRMAPK14 | |
| SCHEMBL20865224 | 0.94 | ENPP1 (0.45) | ENPP1AURKAAURKBEGFRMAPK14 | |
| SCHEMBL1732069 | 0.85 | ENPP1 (0.60) | ENPP1AURKAAURKBEGFRMAPK14 | |
| SCHEMBL8777 | 0.82 | ENPP1 (0.63) | ENPP1EGFRPDE10AKDRRET | |
| SCHEMBL3427630 | 0.82 | ENPP1 (0.63) | ENPP1EGFRPDE10AKDRRET | |
| Hydrochloric Acid SCHEMBL9097 | 0.81 | ENPP1 (0.62) | ENPP1EGFRPDE10AKDRRET | |
| SCHEMBL13915595 | 0.80 | EGFR (0.53) | EGFRCSF1R | |
| SCHEMBL364049 | 0.80 | ENPP1 (0.81) | ENPP1AURKAEGFRMAPK14KDR | |
| SCHEMBL29359187 | 0.80 | ENPP1 (0.81) | ENPP1AURKAEGFRMAPK14KDR | |
| SCHEMBL3428617 | 0.79 | EGFR (0.52) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |