Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11835813 | 0.72 | KMT2A (0.73) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL31522420 | 0.72 | CMKLR1 (0.52) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11837405 | 0.71 | KMT2A (0.61) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL30885684 | 0.71 | POLB (0.44) | KMT2AMAPTL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL20562276 | 0.71 | POLB (0.44) | KMT2AMAPTL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL30912791 | 0.71 | POLB (0.44) | KMT2AMAPTL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL15631853 | 0.71 | KMT2A (1.00) | KMT2AMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL17322842 | 0.71 | SMN1; SMN2 (0.56) | KMT2AMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL11837486 | 0.69 | KMT2A (0.58) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL15631864 | 0.69 | KMT2A (0.76) | KMT2AMAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | CYP11B1, HSP90B1, CYP1B1 | KMT2A 4742/4885MAPT 174/4885L3MBTL1 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.