Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15631845 | 0.91 | KDM4E (0.70) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322866 | 0.88 | KDM4E (0.63) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322880 | 0.86 | KDM4E (0.70) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15631862 | 0.84 | KDM4E (0.70) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322837 | 0.83 | KDM4E (0.69) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322839 | 0.83 | KDM4E (0.69) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15631848 | 0.83 | KDM4E (0.69) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322836 | 0.83 | LMNA (0.59) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17326650 | 0.83 | KDM4E (0.56) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17322846 | 0.82 | KDM4E (0.65) | KDM4EKMT2ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | CYP11B1, HSP90B1, CYP1B1 | KDM4E 4525/4885KMT2A 4742/4885SMN1; SMN2 4794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.