Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 6/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814713 | 0.87 | AXL (0.47) | AXLDYRK1ACLK1HSD11B1GSK3A | |
| SCHEMBL9938142 | 0.84 | AXL (0.63) | AXLSGK1 | |
| SCHEMBL30020999 | 0.84 | AXL (0.63) | AXLSGK1 | |
| SCHEMBL18052042 | 0.84 | AXL (0.39) | AXLDYRK1ACLK1CYP2C19HSD11B1 | |
| SCHEMBL22049462 | 0.84 | AXL (0.42) | AXLDYRK1ACLK1HSD11B1DYRK3 | |
| SCHEMBL22837773 | 0.84 | AXL (0.39) | AXLDYRK1ACLK1CYP2C19HSD11B1 | |
| SCHEMBL17321398 | 0.83 | AXL (0.42) | AXLDYRK1ACLK1CYP2C19HSD11B1 | |
| SCHEMBL19997224 | 0.83 | AXL (0.42) | AXLCLK1CYP2C19CYP2C9DCLK1 | |
| SCHEMBL12146867 | 0.82 | CYP2C19 (0.47) | PIK3CAAXLCYP2C19HASPINPBRM1 | |
| SCHEMBL24197776 | 0.82 | AXL (0.39) | AXLCLK1CYP2C19HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | PIK3CA 193/4885AXL 2131/4885DYRK1A 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.