Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21468119 | 1.00 | APLNR (0.80) | APLNR | |
| SCHEMBL18964208 | 0.90 | APLNR (0.85) | APLNR | |
| SCHEMBL18964195 | 0.90 | APLNR (0.85) | APLNR | |
| SCHEMBL21229230 | 0.89 | APLNR (1.00) | APLNR | |
| SCHEMBL17326453 | 0.89 | APLNR (1.00) | APLNR | |
| SCHEMBL21229232 | 0.87 | APLNR (0.80) | APLNR | |
| SCHEMBL17326434 | 0.87 | APLNR (0.80) | APLNR | |
| SCHEMBL21229198 | 0.85 | APLNR (0.80) | APLNR | |
| SCHEMBL17326321 | 0.85 | APLNR (0.80) | APLNR | |
| SCHEMBL17930685 | 0.84 | APLNR (0.74) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RES TRIANGLE INST (US) | 2019-10-17 | — | — | US | disclosed |
| US-10377718-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2019-08-13 | — | — | US | disclosed |
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2016-07-21 | — | — | US | disclosed |
| WO-2015188073-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | APLNR 1/4885 |
| US-10377718-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | APLNR 1/4885 |
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | APLNR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.