Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17316117 | 1.00 | HDAC9 (1.00) | HDAC9HDAC4HCAR2OPRL1 | |
| SCHEMBL17327651 | 1.00 | HDAC9 (1.00) | HDAC9HDAC4HCAR2OPRL1 | |
| SCHEMBL4432306 | 0.83 | HDAC9 (0.71) | HDAC9HDAC4HCAR2 | |
| SCHEMBL17316049 | 0.80 | HDAC9 (0.67) | HDAC9HCAR2OPRL1 | |
| SCHEMBL18736676 | 0.74 | HDAC9 (0.59) | HDAC9HDAC4 | |
| SCHEMBL11190038 | 0.74 | HDAC9 (0.58) | HDAC9HCAR2 | |
| SCHEMBL14214917 | 0.73 | HDAC9 (0.57) | HDAC9HDAC4HCAR2 | |
| SCHEMBL27359306 | 0.71 | HDAC9 (0.55) | HDAC9OPRL1 | |
| SCHEMBL27728415 | 0.71 | HDAC9 (0.55) | HDAC9HCAR2 | |
| SCHEMBL11565801 | 0.70 | HDAC9 (0.54) | HDAC9HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148539-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10457675-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2017-04-13 | — | — | US | disclosed |
| WO-2015187542-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC. (US) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10457675-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | HDAC1, HDAC7, HDAC2 | HDAC9 8/4885HDAC4 10/4885HCAR2 844/4885 |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC6, HDAC5 | HDAC9 6/4885HDAC4 7/4885HCAR2 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.