Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11190038 | 0.89 | HDAC9 (0.58) | HDAC9AKR1C1HCAR2KIF11KDM1A | |
| SCHEMBL27359306 | 0.85 | HDAC9 (0.55) | HDAC9KIF11 | |
| SCHEMBL27728415 | 0.85 | HDAC9 (0.55) | HDAC9AKR1C1HCAR2KDM1ATSHR | |
| SCHEMBL17316117 | 0.83 | HDAC9 (1.00) | HDAC9HCAR2HDAC4 | |
| SCHEMBL17327651 | 0.83 | HDAC9 (1.00) | HDAC9HCAR2HDAC4 | |
| SCHEMBL17327652 | 0.83 | HDAC9 (1.00) | HDAC9HCAR2HDAC4 | |
| SCHEMBL17316049 | 0.82 | HDAC9 (0.67) | HDAC9HCAR2TDP1 | |
| SCHEMBL11565801 | 0.81 | HDAC9 (0.54) | HDAC9HCAR2KDM1AMAOBTSHR | |
| SCHEMBL14214917 | 0.78 | HDAC9 (0.57) | HDAC9AKR1C1HCAR2KIF11KDM1A | |
| SCHEMBL433287 | 0.76 | HDAC9 (0.50) | HDAC9AKR1C1HCAR2KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148539-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3148539-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10457675-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-10457675-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-10065948-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-09-04 | — | — | US | disclosed |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2017-04-13 | — | — | US | disclosed |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2017-04-13 | — | — | US | disclosed |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2017-04-13 | — | — | US | disclosed |
| EP-3148539-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| CN-106535891-A | Histone deacetylase inhibitors, compositions and methods of use thereof | CHDI基金会股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| US-9599758-B2 | Optical reflective film and optical reflector using the same | Konica Minolta, Inc. (JP) | 2017-03-21 | — | — | US | disclosed |
| WO-2015187542-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC. (US) | 2015-12-10 | — | — | WO | disclosed |
| WO-2015187542-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC. (US) | 2015-12-10 | — | — | WO | disclosed |
| US-20150285974-A1 | OPTICAL REFLECTIVE FILM AND OPTICAL REFLECTOR USING THE SAME | Konica Minolta, Inc. (JP) | 2015-10-08 | — | — | US | disclosed |
| US-8324401-B2 | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-12-04 | — | — | US | disclosed |
| US-20090325961-A1 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-31 | — | — | US | disclosed |
| US-7592461-B2 | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-22 | — | — | US | disclosed |
| US-20070185056-A1 | Indane modulators of glucocorticoid receptor, AP-1, and/or NF/kB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY | 2007-08-09 | — | — | US | disclosed |
| US-4426422-A | Distortion and chemically resistant heat transfer materials | DENNISON MANUFACTURING COMPANY (US) | 1984-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10065948-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | HDAC1, HDAC6, HDAC5 | HDAC9 6/4885AKR1C1 2829/4885HCAR2 800/4885 |
| US-20090325961-A1 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFKB1, NR3C1, NR5A1 | HDAC9 1344/4885AKR1C1 454/4885HCAR2 2845/4885 |
| US-10457675-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | HDAC1, HDAC7, HDAC2 | HDAC9 8/4885AKR1C1 2246/4885HCAR2 844/4885 |
| US-20170101402-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC6, HDAC5 | HDAC9 6/4885AKR1C1 2829/4885HCAR2 800/4885 |
| US-20070185056-A1 | Indane modulators of glucocorticoid receptor, AP-1, and/or NF/kB activity and use thereof | NFKB1, NR3C1, NR5A1 | HDAC9 1302/4885AKR1C1 417/4885HCAR2 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.