Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.51 |
| ▸ | GAK | O14976 | 2/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | BUB1 | O43683 | 2/20 | 0.51 |
| ▸ | STK10 | O94804 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FECH | P22830 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17328028 | 1.00 | EGFR (0.53) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL18400008 | 0.86 | EGFR (0.43) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL17327988 | 0.85 | EGFR (0.49) | EGFRERBB2RETKDRLMNA | |
| SCHEMBL16305164 | 0.84 | EGFR (0.53) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL16305169 | 0.83 | EGFR (0.50) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL16305160 | 0.78 | EGFR (0.53) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL16297199 | 0.77 | EGFR (0.53) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL10118463 | 0.74 | ERBB2 (0.83) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL15365221 | 0.74 | EGFR (0.94) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL15365443 | 0.74 | EGFR (0.94) | EGFRERBB2GAKRIPK2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | RJS BIOLOGICS LLC | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | MIF, HMGB2, HMGB1 | EGFR 1994/4885ERBB2 1829/4885GAK 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.