Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956186 | 1.00 | RBP4 (0.41) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL17328321 | 1.00 | RBP4 (0.41) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL9955490 | 0.95 | CLK2 (0.40) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL9956873 | 0.95 | CLK2 (0.40) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL17328315 | 0.95 | CLK2 (0.40) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL9956651 | 0.91 | RBP4 (0.41) | RBP4IRAK4CLK2LRRK2KCNH2 | |
| SCHEMBL9956696 | 0.91 | RBP4 (0.42) | RBP4CLK2LRRK2KCNH2SCN5A | |
| SCHEMBL9955993 | 0.90 | RBP4 (0.40) | RBP4CLK2LRRK2KCNH2SCN5A | |
| SCHEMBL9956228 | 0.89 | RBP4 (0.45) | RBP4RXFP1CSNK1DCSNK1E | |
| SCHEMBL9957202 | 0.88 | DPP4 (0.42) | RBP4IRAK4CLK2LRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |