Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955779 | 1.00 | RIPK1 (0.38) | RIPK1PTGER4FGFR1MAPTIRAK4 | |
| SCHEMBL9955783 | 1.00 | RIPK1 (0.38) | RIPK1PTGER4FGFR1MAPTIRAK4 | |
| SCHEMBL9956948 | 0.96 | PTGER4 (0.40) | RIPK1PTGER4FGFR1MAPTCSNK1D | |
| SCHEMBL9957049 | 0.91 | CCNC (0.37) | MAPTIRAK4CSNK1DCSNK1EKDR | |
| SCHEMBL9957047 | 0.91 | CCNC (0.37) | MAPTIRAK4CSNK1DCSNK1EKDR | |
| SCHEMBL17328316 | 0.90 | KCNH2 (0.38) | RIPK1MAPTCSNK1DCSNK1EKDR | |
| SCHEMBL9956308 | 0.90 | KCNH2 (0.38) | RIPK1MAPTCSNK1DCSNK1EKDR | |
| SCHEMBL17328329 | 0.90 | KCNH2 (0.38) | RIPK1MAPTCSNK1DCSNK1EKDR | |
| SCHEMBL9956578 | 0.89 | KDR (0.39) | MAPTCSNK1DCSNK1EKDRDPP4 | |
| SCHEMBL9956873 | 0.89 | CLK2 (0.40) | IRAK4CSNK1DCSNK1EDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |