Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340425 | 0.86 | CA2 (0.46) | CA2SIRT1 | |
| SCHEMBL1115062 | 0.86 | CA2 (0.46) | CA2MAPK8 | |
| Hydrochloric Acid SCHEMBL3341453 | 0.84 | IDO1 (0.45) | CA2SIRT1 | |
| Hydrochloric Acid SCHEMBL6256367 | 0.84 | MAPK8 (0.45) | CA2MAPK8 | |
| SCHEMBL156863 | 0.82 | FFAR4 (0.43) | METAP2CA2DAOFFAR4 | |
| SCHEMBL5411388 | 0.81 | CA2 (0.39) | CA2SIRT1 | |
| SCHEMBL14109398 | 0.81 | DAO (0.36) | METAP2AURKARPS6KB1DAOGPR52 | |
| SCHEMBL1651345 | 0.78 | CA2 (0.50) | CA2SIRT1 | |
| SCHEMBL31421901 | 0.77 | CA2 (0.39) | CA2SIRT1 | |
| SCHEMBL3932314 | 0.77 | CA2 (0.39) | CA2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |