Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057456 | 0.83 | NOTUM (0.38) | EPHX2HDAC6GRIN1GRIN2B | |
| SCHEMBL1783046 | 0.79 | POLB (0.34) | ALDH1A1SMN1; SMN2NPSR1RECQLLOXL2 | |
| SCHEMBL14410036 | 0.79 | EPHX2 (0.33) | EPHX2HDAC6 | |
| Hydrochloric Acid SCHEMBL3718065 | 0.78 | POLB (0.36) | ALDH1A1SMN1; SMN2NPSR1RECQLLOXL2 | |
| SCHEMBL24302233 | 0.76 | NOTUM (0.39) | EPHX2HDAC6GRIN1GRIN2B | |
| SCHEMBL725711 | 0.74 | ALDH1A1 (0.38) | ALDH1A1EPHX2HDAC6GRIN1GRIN2B | |
| SCHEMBL13494151 | 0.71 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NPSR1RECQLLOXL2 | |
| SCHEMBL1829308 | 0.71 | EPHX2 (0.45) | EPHX2HDAC6 | |
| SCHEMBL18367824 | 0.71 | EPHX2 (0.33) | EPHX2HDAC6GRIN1GRIN2B | |
| SCHEMBL7885449 | 0.71 | EPHX2 (0.33) | EPHX2HDAC6GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |