SCHEMBL1732964

SCHEMBL1732964

COc1nc(Cl)cnc1N(COCC[Si](C)(C)C)S(=O)(=O)c1cccc(Cl)c1Cl.COc1nc(OCCN)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 19/20 0.57
EDNRA P25101 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1733387 0.86 CCR4 (0.52) CCR4
SCHEMBL1732245 0.82 CCR4 (0.79) CCR4
SCHEMBL4704825 0.80 CCR4 (0.44) CCR4
SCHEMBL4704820 0.80 CCR4 (0.44) CCR4
SCHEMBL1733005 0.78 CCR4 (0.53) CCR4EDNRA
SCHEMBL5907751 0.78 CCR4 (0.50) CCR4
SCHEMBL1733157 0.77 CCR4 (0.51) CCR4
SCHEMBL1733421 0.77 CCR4 (0.56) CCR4
SCHEMBL1732492 0.76 CCR4 (1.00) CCR4
SCHEMBL4699938 0.75 CCR4 (0.39) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1467976-B1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES ASTRAZENECA AB (SE) 2011-11-23 EP disclosed
WO-2011081310-A3 PEPTIDE MARKER FOR CANCER DIAGNOSIS, AND CANCER DIAGNOSIS METHOD USING SAME 한국기초과학지원연구원 (KR) 2011-10-27 WO disclosed
EP-1467976-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES AstraZeneca AB (SE) 2004-10-20 EP disclosed
WO-2003059893-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES ASTRAZENECA AB (SE) 2003-07-24 WO disclosed