Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419111 | 0.88 | MAPT (0.42) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL1733154 | 0.86 | HDAC3 (0.43) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL1734149 | 0.81 | SCN9A (0.41) | RAB9ANPC1MAPTALDH1A1LMNA | |
| SCHEMBL3778417 | 0.81 | CYP2C9 (0.56) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL3773727 | 0.81 | KDM4E (0.44) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL10961762 | 0.76 | PI4KB (0.44) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL7472746 | 0.74 | RAB9A (0.50) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL17548274 | 0.74 | KMT2A (0.55) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL8321552 | 0.72 | MAPT (0.66) | RAB9ANPC1MAPTPKMHDAC3 | |
| SCHEMBL8318198 | 0.72 | HDAC3 (0.50) | RAB9ANPC1MAPTPKMHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| EP-2225243-B1 | Derivatives of N-heterocyclic-6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-11-16 | — | — | EP | claimed |