Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734174 | 0.82 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL1733748 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1HPGDHTTGPR55 | |
| SCHEMBL1734432 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1733464 | 0.78 | KDM4E (0.70) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL1733617 | 0.77 | KDM4E (0.69) | KDM4ELMNAGRM2ADORA2AADORA1 | |
| SCHEMBL3724502 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL1733755 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL1734590 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL1733665 | 0.74 | KDM4E (0.64) | KDM4EMEN1KMT2AGRM2ADORA2A | |
| SCHEMBL3720267 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891018-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2011-11-16 | — | — | EP | claimed |
| WO-2011131686-A1 | A THERMALLY CONTROLLED ASSEMBLY | NAPATECH A/S (DK) | 2011-10-27 | — | — | WO | claimed |