SCHEMBL17338200

SCHEMBL17338200

NCCc1nc2cccc(Cl)c2c(=O)n1N1CCN(CC(F)(F)F)CC1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.54
PIK3R2 O00459 7/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17338314 0.90 PIK3CD (0.53) PIK3CDPIK3R2
SCHEMBL17338194 0.85 PIK3CD (0.52) PIK3CDPIK3R2
SCHEMBL17338385 0.84 PIK3CD (0.48) PIK3CDPIK3R2
SCHEMBL15819765 0.84 PIK3CD (0.42) PIK3CDPIK3R2
SCHEMBL15818419 0.82 PIK3CD (0.49) PIK3CDPIK3R2
SCHEMBL15819733 0.82 PIK3R2 (0.51) PIK3CDPIK3R2
SCHEMBL17338155 0.82 PIK3CD (0.56) PIK3CDPIK3R2
SCHEMBL17338266 0.82 PIK3CD (0.59) PIK3CDPIK3R2
SCHEMBL17338159 0.81 PIK3CD (0.52) PIK3CDPIK3R2
SCHEMBL17330982 0.81 PIK3CD (0.67) PIK3CDPIK3R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154958-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS Gilead Sciences, Inc. (US) 2017-04-19 EP disclosed
WO-2015191752-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD SCIENCES, INC. (US) 2015-12-17 WO disclosed