SCHEMBL17338266

SCHEMBL17338266

Nc1nc(N)c(Cl)c(NCCc2nc3cccc(Cl)c3c(=O)n2N2CCN(CC(F)(F)F)CC2)n1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.59
PIK3R2 O00459 8/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17338343 0.91 PIK3CD (0.70) PIK3CDPIK3R2
SCHEMBL17338480 0.89 PIK3CD (0.70) PIK3CDPIK3R2
SCHEMBL17338438 0.89 PIK3CD (0.59) PIK3CDPIK3R2
SCHEMBL17338301 0.86 PIK3CD (0.72) PIK3CDPIK3R2
SCHEMBL17338311 0.86 PIK3CD (0.65) PIK3CDPIK3R2
SCHEMBL17338278 0.86 PIK3CD (0.60) PIK3CDPIK3R2
SCHEMBL17338186 0.82 PIK3CD (0.48) PIK3CDPIK3R2
SCHEMBL17338200 0.82 PIK3CD (0.54) PIK3CDPIK3R2
SCHEMBL17330581 0.82 PIK3CD (0.83) PIK3CDPIK3R2
SCHEMBL17330579 0.82 PIK3CD (0.83) PIK3CDPIK3R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154958-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS Gilead Sciences, Inc. (US) 2017-04-19 EP claimed
WO-2015191752-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD SCIENCES, INC. (US) 2015-12-17 WO claimed