Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.52 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338152 | 0.91 | PIK3CD (0.50) | PIK3CDPIK3R2FAAHPRKAA2 | |
| SCHEMBL17338222 | 0.91 | PIK3CD (0.47) | PIK3CDPIK3R2DRD4 | |
| SCHEMBL17338166 | 0.87 | PIK3CD (0.49) | PIK3CDPIK3R2FAAHDRD4SIGMAR1 | |
| SCHEMBL17338359 | 0.87 | PIK3CD (0.52) | PIK3CDPIK3R2FAAHSIGMAR1 | |
| SCHEMBL17338167 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3R2 | |
| SCHEMBL17338194 | 0.82 | PIK3CD (0.52) | PIK3CDPIK3R2 | |
| SCHEMBL17338353 | 0.82 | PIK3CD (0.71) | PIK3CDPIK3R2 | |
| SCHEMBL17338209 | 0.81 | PIK3R2 (0.49) | PIK3CDPIK3R2 | |
| SCHEMBL17338226 | 0.79 | PIK3CD (0.52) | PIK3CDPIK3R2 | |
| SCHEMBL17338163 | 0.79 | PIK3CD (0.49) | PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |