Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 12/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338260 | 0.87 | PIK3CD (0.40) | PIK3R2PIK3CD | |
| SCHEMBL17338149 | 0.86 | PDE10A (0.35) | PDE10APIK3R2PIK3CD | |
| SCHEMBL22519315 | 0.79 | PDE10A (0.35) | PDE10APIK3R2PIK3CD | |
| SCHEMBL17338385 | 0.74 | PIK3CD (0.48) | PIK3R2PIK3CD | |
| SCHEMBL17338397 | 0.74 | POLB (0.41) | PDE10APIK3R2PIK3CD | |
| SCHEMBL15819765 | 0.72 | PIK3CD (0.42) | PDE10AKCNH2HRH3PIK3R2PIK3CD | |
| SCHEMBL17330564 | 0.72 | PIK3R2 (0.43) | PIK3R2PIK3CD | |
| SCHEMBL17330566 | 0.72 | PIK3R2 (0.43) | PIK3R2PIK3CD | |
| SCHEMBL17338188 | 0.71 | POLB (0.40) | PDE10APIK3R2PIK3CD | |
| SCHEMBL17338155 | 0.70 | PIK3CD (0.56) | KCNH2HRH3PIK3R2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |