Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338188 | 0.95 | POLB (0.40) | POLBPIK3R2STSPIK3CDPDE10A | |
| SCHEMBL17338298 | 0.90 | PIK3R2 (0.40) | POLBPIK3R2STSPIK3CDPDE10A | |
| SCHEMBL17338168 | 0.87 | POLB (0.40) | POLBSTSPARP1KDM1ADPP4 | |
| SCHEMBL17338149 | 0.86 | PDE10A (0.35) | PIK3R2PIK3CDPDE10APARP1TNKS2 | |
| SCHEMBL17338394 | 0.84 | CYP3A4 (0.40) | POLBPIK3R2STSPIK3CDKDM1A | |
| SCHEMBL17338223 | 0.84 | OPRM1 (0.44) | STSPIK3CDPARP1 | |
| SCHEMBL17338215 | 0.83 | PIK3CD (0.50) | PIK3R2PIK3CD | |
| SCHEMBL17338186 | 0.83 | PIK3CD (0.48) | PIK3R2PIK3CD | |
| SCHEMBL17338254 | 0.83 | PIK3R2 (0.51) | PIK3R2PIK3CD | |
| SCHEMBL17338250 | 0.82 | PIK3CD (0.48) | PIK3R2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |