Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.76 |
| ▸ | FLT1 | P17948 | 8/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966781 | 0.90 | EGFR (0.76) | EGFRFLT1PIK3CAPIK3CGRET | |
| SCHEMBL8093519 | 0.86 | EGFR (1.00) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| SCHEMBL3606262 | 0.84 | EGFR (0.73) | EGFRFLT1PIK3CAPIK3CGKDR | |
| Hydrochloric Acid SCHEMBL8593958 | 0.82 | EGFR (0.72) | EGFRFLT1KDR | |
| SCHEMBL8976304 | 0.82 | EGFR (0.71) | EGFRFLT1PIK3CAPIK3CGRET | |
| Hydrochloric Acid SCHEMBL8976476 | 0.81 | EGFR (0.70) | EGFRFLT1PIK3CAPIK3CGRET | |
| SCHEMBL27545981 | 0.81 | EGFR (0.69) | EGFRFLT1PIK3CAPIK3CGRET | |
| SCHEMBL31514622 | 0.81 | EGFR (0.69) | EGFRFLT1PIK3CAPIK3CGRET | |
| SCHEMBL8976448 | 0.80 | EGFR (0.67) | EGFRFLT1PIK3CAPIK3CGRET | |
| SCHEMBL7976800 | 0.80 | RET (0.70) | EGFRFLT1RETKDRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318932-B2 | Process for producing 4-aminoquinazoline compound | UBE INDUSTRIES, LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-1481971-B1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES (JP) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011131610-A1 | HEAT TRANSFER MEDIUM BASED ON SULPHUR AND USE OF THE HEAT TRANSFER MEDIUM | SIEMENS AKTIENGESELLSCHAFT (DE) | 2011-10-27 | — | — | WO | disclosed |
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2008-07-24 | — | — | US | disclosed |
| US-20050130995-A1 | Chlorinating quinazolin-4-one in solvent in presence of a base; then reacting with an amine compound | UBE INDUSTRIES, LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1481971-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | Ube Industries, Ltd. (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | EGFR 1101/4885FLT1 1261/4885PIK3CA 642/4885 |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | EGFR 1101/4885FLT1 1261/4885PIK3CA 642/4885 |
| US-20050130995-A1 | Chlorinating quinazolin-4-one in solvent in presence of a base; then reacting with an amine compound | HRH4, HRH3, H1-4 | EGFR 543/4885FLT1 1254/4885PIK3CA 579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.