Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081980 | 0.90 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL7978781 | 0.88 | EGFR (0.78) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| SCHEMBL7978783 | 0.88 | EGFR (0.78) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| SCHEMBL1733829 | 0.86 | EGFR (0.76) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| SCHEMBL8082013 | 0.85 | EGFR (0.74) | EGFRFLT1ERBB2 | |
| SCHEMBL3606262 | 0.85 | EGFR (0.73) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| Hydrochloric Acid SCHEMBL8593958 | 0.84 | EGFR (0.72) | EGFRFLT1 | |
| SCHEMBL8976304 | 0.83 | EGFR (0.71) | EGFRFLT1PIK3CAPIK3CGERBB2 | |
| SCHEMBL7021509 | 0.83 | EGFR (0.70) | EGFRFLT1 | |
| Hydrochloric Acid SCHEMBL8976476 | 0.82 | EGFR (0.70) | EGFRFLT1PIK3CAPIK3CGERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |