SCHEMBL17338301

SCHEMBL17338301

Cc1nc(N)nc(NCCc2nc3cccc(Cl)c3c(=O)n2N2CCN(CC(F)(F)F)CC2)c1C#N

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.72
PIK3R2 O00459 9/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17338480 0.94 PIK3CD (0.70) PIK3CDPIK3R2
SCHEMBL17338343 0.93 PIK3CD (0.70) PIK3CDPIK3R2
SCHEMBL17338383 0.87 PIK3CD (0.73) PIK3CDPIK3R2
SCHEMBL17338266 0.86 PIK3CD (0.59) PIK3CDPIK3R2
SCHEMBL17338353 0.86 PIK3CD (0.71) PIK3CDPIK3R2
SCHEMBL20525245 0.85 PIK3CD (0.70) PIK3CDPIK3R2
SCHEMBL17330639 0.84 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17330642 0.84 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17338246 0.84 PIK3CD (0.67) PIK3CDPIK3R2
SCHEMBL17338187 0.83 PIK3CD (0.72) PIK3CDPIK3R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154958-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS Gilead Sciences, Inc. (US) 2017-04-19 EP claimed
WO-2015191752-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD SCIENCES, INC. (US) 2015-12-17 WO claimed