Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.70 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.70 |
| ▸ | PPARG | P37231 | 2/20 | 0.61 |
| ▸ | PPARA | Q07869 | 2/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339665 | 0.85 | HTR2C (0.63) | EPHX2NR1H4TRPV1HTR2CNAMPT | |
| SCHEMBL20477570 | 0.85 | EPHX2 (0.76) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL20477542 | 0.84 | EPHX2 (0.74) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL95452 | 0.84 | EPHX2 (0.74) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL3577590 | 0.83 | EPHX2 (0.73) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL27920874 | 0.83 | MAPK14 (0.74) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL17339455 | 0.83 | TRPV1 (0.66) | EPHX2NR1H4PPARGPPARATRPV1 | |
| SCHEMBL13764237 | 0.82 | NPC1 (0.68) | EPHX2NR1H4PPARGTRPV1ALDH1A1 | |
| SCHEMBL17339577 | 0.82 | NPC1 (0.68) | EPHX2NR1H4PPARGTRPV1ALDH1A1 | |
| SCHEMBL28649243 | 0.82 | EPHX2 (0.70) | EPHX2NR1H4PPARGPPARATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119281-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | LOXO ONCOLOGY INC (US) | 2019-04-25 | — | — | US | disclosed |
| EP-3154978-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BRUTON'S TYROSINE KINASE | LOXO ONCOLOGY INC (US) | 2019-04-03 | — | — | EP | disclosed |
| US-9975897-B2 | Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase | LOXO ONCOLOGY, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170129897-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | LOXO ONCOLOGY, INC. | 2017-05-11 | — | — | US | disclosed |
| EP-3154978-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BRUTON'S TYROSINE KINASE | Redx Pharma Plc (GB) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015189620-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BRUTON'S TYROSINE KINASE | REDX PHARMA PLC (GB) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119281-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LCK | EPHX2 2580/4885NR1H4 4501/4885PPARG 4186/4885 |
| US-20170129897-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LCK | EPHX2 2580/4885NR1H4 4501/4885PPARG 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.