Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.74 |
| ▸ | XPNPEP2 | O43895 | 2/20 | 0.74 |
| ▸ | REN | P00797 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PEPD | P12955 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339958 | 0.86 | ACE (1.00) | ACEXPNPEP2RENKDM4EF2 | |
| SCHEMBL6679094 | 0.84 | DPP4 (0.58) | ACEXPNPEP2RENKDM4EF2 | |
| SCHEMBL6679097 | 0.84 | DPP4 (0.58) | ACEXPNPEP2RENKDM4EF2 | |
| SCHEMBL17339959 | 0.83 | ACE (0.61) | ACEXPNPEP2RENKDM4EF2 | |
| SCHEMBL10795143 | 0.81 | ACE (0.89) | ACERENKDM4EF2LMNA | |
| SCHEMBL12191488 | 0.80 | ACE (0.72) | ACERENKDM4EF2LMNA | |
| SCHEMBL15223630 | 0.80 | ACE (0.72) | ACERENKDM4EF2LMNA | |
| SCHEMBL10658601 | 0.79 | ACE (0.57) | ACERENKDM4EF2LMNA | |
| SCHEMBL30139015 | 0.79 | ACE (0.57) | ACERENKDM4EF2LMNA | |
| SCHEMBL31401997 | 0.79 | ACE (0.57) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212206-B1 | 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use | SIMMONS WILLIAM H (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212206-B1 | 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use | SIMMONS WILLIAM H (US) | 2015-12-15 | — | — | US | disclosed |