Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 14/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271837 | 0.81 | SYK (0.46) | SYKKCNH2AURKBZAP70MAPK3 | |
| SCHEMBL10272159 | 0.81 | SYK (0.59) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL2716538 | 0.81 | SYK (0.50) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL2728647 | 0.79 | SYK (0.48) | SYK | |
| SCHEMBL2728643 | 0.79 | SYK (0.48) | SYK | |
| SCHEMBL2717937 | 0.78 | SYK (0.42) | ADORA3SYKKCNH2AURKBZAP70 | |
| SCHEMBL2718568 | 0.77 | SYK (0.41) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL1949965 | 0.74 | LMNA (0.49) | SYKKCNH2AURKBZAP70KDR | |
| SCHEMBL10127056 | 0.74 | GFER (0.47) | SYKEGFR | |
| SCHEMBL17069448 | 0.73 | LMNA (0.48) | SYKKCNH2AURKBZAP70KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-12-16 | — | — | EP | disclosed |