Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.53 |
| ▸ | ROS1 | P08922 | 7/20 | 0.53 |
| ▸ | FLT3 | P36888 | 7/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.53 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282875 | 0.90 | RET (0.55) | RETROS1FLT3ALKEML4 | |
| SCHEMBL10127376 | 0.83 | EML4 (0.67) | RETROS1FLT3ALKEML4 | |
| SCHEMBL10128020 | 0.83 | RET (0.69) | RETROS1FLT3ALKEML4 | |
| SCHEMBL10127384 | 0.82 | RET (0.54) | RETROS1FLT3ALKEML4 | |
| SCHEMBL10128030 | 0.81 | RET (0.61) | RETROS1FLT3ALKEML4 | |
| SCHEMBL15134661 | 0.80 | EML4 (0.63) | RETROS1FLT3ALKEML4 | |
| SCHEMBL17690587 | 0.79 | SLC2A1 (0.58) | RETROS1FLT3ALKEML4 | |
| SCHEMBL28891673 | 0.78 | RET (0.58) | RETROS1FLT3ALKEML4 | |
| SCHEMBL29875589 | 0.78 | RET (0.58) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562764 | 0.77 | RET (0.63) | RETROS1FLT3ALKEML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-12-16 | — | — | EP | disclosed |