Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | CTSD | P07339 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | DHODH | Q02127 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232928 | 0.89 | MAOB (0.66) | HSD17B10CYP1A2TRPV1CYP3A4MAOB | |
| SCHEMBL30579629 | 0.89 | MAOB (0.66) | HSD17B10CYP1A2TRPV1CYP3A4MAOB | |
| SCHEMBL1232929 | 0.89 | MAOB (0.66) | HSD17B10CYP1A2TRPV1CYP3A4MAOB | |
| Piperic Acid SCHEMBL288595 | 0.86 | HSD17B10 (1.00) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| Piperic Acid SCHEMBL11460093 | 0.86 | HSD17B10 (1.00) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| Piperic Acid SCHEMBL29429112 | 0.86 | HSD17B10 (1.00) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| Piperic Acid SCHEMBL11460092 | 0.86 | HSD17B10 (1.00) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| Piperic Acid SCHEMBL447578 | 0.86 | HSD17B10 (1.00) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| SCHEMBL24601639 | 0.85 | HSD17B10 (0.76) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 | |
| SCHEMBL1344559 | 0.85 | HSD17B10 (0.76) | HSD17B10CYP1A2HDAC6GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519511-B1 | NOVEL PIPERINE DERIVATIVES AS GABA-A RECEPTORS MODULATORS | Universität Wien (AT) | 2015-12-16 | — | — | EP | disclosed |