Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.93 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.93 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.93 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.93 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.93 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340474 | 0.99 | GABRA1 (0.91) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL17340468 | 0.99 | GABRA1 (0.91) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11434928 | 0.97 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11460179 | 0.97 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL17340454 | 0.97 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11460180 | 0.97 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11459629 | 0.92 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11434793 | 0.92 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL13332829 | 0.92 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL11459628 | 0.92 | GABRA1 (1.00) | GABRA1GABRB2GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519511-B1 | NOVEL PIPERINE DERIVATIVES AS GABA-A RECEPTORS MODULATORS | Universität Wien (AT) | 2015-12-16 | — | — | EP | disclosed |