Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280550 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTKDM4EEPHX1EPHX2 | |
| SCHEMBL22520374 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTKDM4EEPHX1EPHX2 | |
| SCHEMBL16015490 | 0.81 | ADRB2 (0.48) | SMN1; SMN2HTTKDM4EMEN1KMT2A | |
| SCHEMBL31206390 | 0.80 | — | — | |
| SCHEMBL31206703 | 0.80 | — | — | |
| SCHEMBL16130796 | 0.80 | — | — | |
| SCHEMBL20991788 | 0.79 | HRH3 (0.40) | SMN1; SMN2HTTKDM4EMAPTADRB2 | |
| SCHEMBL19966125 | 0.79 | HTT (0.40) | SMN1; SMN2HTTKDM4EADRB2ADRB1 | |
| SCHEMBL22570101 | 0.76 | HTT (0.38) | SMN1; SMN2HTTKDM4EADRB2ADRB1 | |
| SCHEMBL17743438 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955183-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |