Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.73 |
| ▸ | CTSS | P25774 | 5/20 | 0.54 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723731 | 1.00 | SYK (0.73) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL2723729 | 1.00 | SYK (0.73) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL18493990 | 1.00 | SYK (0.73) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL2723154 | 0.90 | SYK (0.71) | SYKCTSSCTSLCTSBCTSK | |
| SCHEMBL2725000 | 0.90 | SYK (0.71) | SYKCTSSCTSLCTSBCTSK | |
| SCHEMBL2723152 | 0.90 | SYK (0.71) | SYKCTSSCTSLCTSBCTSK | |
| SCHEMBL17596414 | 0.87 | CTSS (0.59) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL17596415 | 0.87 | CTSS (0.59) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL13174964 | 0.85 | SYK (0.68) | SYKCTSSCTSLCTSBMEN1 | |
| SCHEMBL10289999 | 0.85 | SYK (0.68) | SYKCTSSCTSLCTSBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955183-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |