Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.81 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.79 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.79 |
| ▸ | HRH2 | P25021 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17348104 | 0.96 | CHRM5 (0.85) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL18782191 | 0.96 | CHRM5 (0.85) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL17348150 | 0.92 | CHRM5 (0.92) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL18782441 | 0.91 | MITF (0.78) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL2363355 | 0.90 | MITF (1.00) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL17348163 | 0.88 | MITF (0.78) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL18782230 | 0.88 | MITF (0.78) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL17348101 | 0.88 | MITF (0.78) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL2363171 | 0.88 | MITF (1.00) | MITFCHRM5ADRA2AADRA2CSLC6A2 | |
| SCHEMBL17348070 | 0.88 | CHRM5 (1.00) | MITFCHRM5ADRA2AADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015192077-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-12-17 | — | — | WO | disclosed |