Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDXK | O00764 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17348540 | 0.71 | ERN1 (0.43) | KDM4EL3MBTL1NPC1RAB9AMCL1 | |
| SCHEMBL17348618 | 0.70 | EP300 (0.41) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL13313257 | 0.69 | ERN1 (0.37) | KDM4ELMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL13313263 | 0.67 | MMP14 (0.39) | KDM4ELMNAMAPTTP53ALOX12 | |
| SCHEMBL13313253 | 0.67 | MAPT (0.42) | KDM4ELMNAMAPTTP53ALOX12 | |
| SCHEMBL13313223 | 0.66 | KDM4E (0.47) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL3234149 | 0.66 | HSP90AA1 (0.53) | KDM4ELMNAMAPTGAAHTT | |
| SCHEMBL9343167 | 0.66 | KDM4E (0.53) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL17348574 | 0.63 | HMGB1 (0.44) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL28176993 | 0.63 | EP300 (0.39) | KDM4ELMNAMAPTTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015191640-A2 | BICYCLIC XANTHINE OXIDASE INHIBITORS AND METHODS OF USE | BAYLOR COLLEGE OF MEDICINE (US) | 2015-12-17 | — | — | WO | disclosed |