Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17349617 | 0.89 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL17349613 | 0.84 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL10486105 | 0.83 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL18750344 | 0.82 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL17349699 | 0.82 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL17349616 | 0.80 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1NPC1RECQLALDH1A1 | |
| SCHEMBL17349695 | 0.77 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1NPC1GAAAGPAT2 | |
| SCHEMBL3943444 | 0.73 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1NPC1GAAAGPAT2 | |
| SCHEMBL17349698 | 0.72 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1NPC1GAAAGPAT2 | |
| SCHEMBL17349497 | 0.71 | HSP90AB1 (0.59) | HSP90AA1HSP90AB1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015192119-A1 | PYRIMIDINE COMPOUNDS AND METHODS USING THE SAME | YUMA THERAPEUTICS, INC. (US) | 2015-12-17 | — | — | WO | disclosed |