Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
| ▸ | CLK2 | P49760 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350795 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350680 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350608 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350483 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350507 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350640 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350588 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350661 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350440 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL17350304 | 1.00 | KCNH2 (0.65) | KCNH2KDM4EHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087165-B2 | Fluoroquinolones and use thereof to treat bacterial infections | SORBONNE UNIVERSITE (FR) | 2018-10-02 | — | — | US | claimed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | claimed |
| EP-3157911-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | Université Pierre et Marie Curie - Paris 6 (UPMC) (FR) | 2017-04-26 | — | — | EP | claimed |
| EP-2957561-A1 | Novel fluoroquinolones and use thereof to treat bacterial infections | Université Paris 6 Pierre et Marie Curie UPMC (FR) | 2015-12-23 | — | — | EP | claimed |
| WO-2015193454-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2015-12-23 | — | — | WO | claimed |
| US-10087165-B2 | Fluoroquinolones and use thereof to treat bacterial infections | SORBONNE UNIVERSITE (FR) | 2018-10-02 | — | — | US | disclosed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | disclosed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | disclosed |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2017-05-25 | — | — | US | disclosed |
| EP-3157911-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | Université Pierre et Marie Curie - Paris 6 (UPMC) (FR) | 2017-04-26 | — | — | EP | disclosed |
| EP-2957561-A1 | Novel fluoroquinolones and use thereof to treat bacterial infections | Université Paris 6 Pierre et Marie Curie UPMC (FR) | 2015-12-23 | — | — | EP | disclosed |
| EP-2957561-A1 | Novel fluoroquinolones and use thereof to treat bacterial infections | Université Paris 6 Pierre et Marie Curie UPMC (FR) | 2015-12-23 | — | — | EP | disclosed |
| WO-2015193454-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015193454-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) (FR) | 2015-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10087165-B2 | Fluoroquinolones and use thereof to treat bacterial infections | CFTR, NQO2, FPR1 | KCNH2 4262/4885KDM4E 3086/4885HPGD 755/4885 |
| US-20170144992-A1 | NOVEL FLUOROQUINOLONES AND USE THEREOF TO TREAT BACTERIAL INFECTIONS | CFTR, IRF3, FPR1 | KCNH2 4615/4885KDM4E 3242/4885HPGD 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.