Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | DRD4 | P21917 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10244051 | 1.00 | DRD2 (0.61) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL10243883 | 0.93 | POLB (0.57) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL17350984 | 0.93 | POLB (0.57) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL10244560 | 0.88 | POLB (0.52) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL17351017 | 0.88 | POLB (0.52) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL10243827 | 0.86 | POLB (0.51) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL10243880 | 0.86 | POLB (0.51) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL10244006 | 0.86 | POLB (0.51) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL17351021 | 0.86 | POLB (0.51) | DRD2DRD4POLBSLC18A3SIGMAR1 | |
| SCHEMBL17350934 | 0.86 | POLB (0.51) | DRD2DRD4POLBSLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |