Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CUL4A | Q13619 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17351380 | 0.99 | PDE9A (0.62) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL17351319 | 0.88 | PDE9A (0.67) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL15573256 | 0.86 | PDE9A (0.61) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL17351326 | 0.85 | PDE9A (0.74) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL17351484 | 0.83 | PDE9A (0.76) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL19953000 | 0.81 | PDE9A (0.71) | PDE9AIDO1HSD11B1ALDH1A1APOBEC3G | |
| SCHEMBL17351433 | 0.78 | CUL4A (0.72) | PDE9AHSD11B1ALDH1A1APOBEC3GGAA | |
| SCHEMBL18060293 | 0.78 | PDE9A (0.70) | PDE9AHSD11B1ALDH1A1APOBEC3GGAA | |
| SCHEMBL17351400 | 0.77 | PDE9A (0.70) | PDE9AHSD11B1ALDH1A1APOBEC3GGAA | |
| SCHEMBL17351455 | 0.77 | PDE9A (0.65) | PDE9AHSD11B1ALDH1A1APOBEC3GGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| US-20150368256-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368256-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | CACNA1E, CHRM1, CHRM2 | PDE9A 918/4885IDO1 1470/4885HSD11B1 4437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.