Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.92 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.92 |
| ▸ | HPGD | P15428 | 10/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6252358 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL1177057 | 0.96 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL6250232 | 0.88 | KDM4E (0.79) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL31120389 | 0.86 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL6252385 | 0.86 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL31120380 | 0.85 | KDM4E (0.76) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL17351540 | 0.84 | KDM4E (0.71) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL6252484 | 0.83 | KDM4E (0.73) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL6250908 | 0.82 | KDM4E (0.92) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL16295335 | 0.82 | KDM4E (0.71) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| US-20150368256-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368256-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | CACNA1E, CHRM1, CHRM2 | KDM4E 2736/4885HSD17B10 3662/4885ALDH1A1 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.