Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | IGF1R | P08069 | 6/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354489 | 0.90 | ABL1 (0.38) | — | |
| SCHEMBL17486551 | 0.90 | IGF1R (0.35) | LMNANPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL17354480 | 0.89 | IGF1R (0.36) | LMNANPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL14853463 | 0.84 | HTT (0.32) | KMT2AMEN1ALDH1A1CHEK1MAPT | |
| SCHEMBL17354473 | 0.82 | IGF1R (0.37) | CHEK1IGF1RROCK2LIMK1 | |
| SCHEMBL13725 | 0.81 | IDH2 (0.38) | IGF1R | |
| SCHEMBL14853169 | 0.81 | RAB9A (0.38) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17354144 | 0.80 | PTGER3 (0.37) | ALDH1A1MAPT | |
| SCHEMBL14075 | 0.79 | KIT (0.38) | — | |
| SCHEMBL13706 | 0.79 | KIT (0.38) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |