Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14853415 | 0.87 | SCN10A (0.37) | GPR3MAOBAOC3HRH4SLC6A4 | |
| SCHEMBL14853412 | 0.84 | CHRM5 (0.38) | GPR3MAOBAOC3HRH4SLC6A4 | |
| SCHEMBL13654 | 0.82 | SCN10A (0.34) | GPR3MAOBAOC3SLC6A4SLC6A3 | |
| SCHEMBL22299305 | 0.79 | HDAC3 (0.43) | GPR3CHRM2CHRM1CHRM3PTGS1 | |
| SCHEMBL14853288 | 0.78 | GLS (0.36) | MAOBAOC3SLC6A4SLC6A2KDM4E | |
| SCHEMBL14853291 | 0.78 | TACR1 (0.36) | GPR3MAOBAOC3HRH4SLC6A4 | |
| SCHEMBL14853147 | 0.76 | MAOB (0.37) | GPR3MAOBAOC3HRH4SLC6A4 | |
| SCHEMBL16959631 | 0.75 | FFAR4 (0.44) | GPR3NOS3NOS1NOS2PIM1 | |
| SCHEMBL21617029 | 0.73 | FFAR4 (0.43) | GPR3HRH4SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL178278 | 0.72 | FFAR4 (0.44) | GPR3NOS3NOS1NOS2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |