Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354955 | 1.00 | AURKB (0.46) | AURKBAURKAKDM1ASMN1; SMN2KMT2A | |
| SCHEMBL6502392 | 0.80 | MAPK10 (0.52) | AURKAKDM1AMAPK8MAPK10KDM4E | |
| SCHEMBL13153524 | 0.71 | KDM4E (0.60) | AURKBAURKAATMNPSR1ROCK2 | |
| SCHEMBL2511703 | 0.69 | AURKB (0.59) | AURKBAURKAATMNPSR1ROCK1 | |
| SCHEMBL17444762 | 0.68 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2AHIF1APRMT5KDM4E | |
| SCHEMBL1225418 | 0.68 | ROCK2 (0.73) | ATMNPSR1ROCK2ROCK1KDM4E | |
| SCHEMBL12786062 | 0.66 | HSD17B10 (0.45) | AURKBAURKAATMNPSR1MAPK8 | |
| SCHEMBL9584160 | 0.66 | AURKB (0.51) | AURKBAURKASMN1; SMN2KMT2AHIF1A | |
| SCHEMBL28655449 | 0.66 | AURKB (0.55) | AURKBAURKAKDM1ASMN1; SMN2KMT2A | |
| SCHEMBL12846288 | 0.65 | ROCK2 (0.42) | AURKBAURKASMN1; SMN2KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771175-B1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-23 | — | — | EP | disclosed |