⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20293776 | 1.00 | — | — | |
| SCHEMBL22730707 | 0.75 | CA2 (0.32) | — | |
| SCHEMBL10277770 | 0.72 | — | — | |
| SCHEMBL23392522 | 0.72 | — | — | |
| SCHEMBL15936997 | 0.72 | — | — | |
| SCHEMBL1850702 | 0.69 | SCN4A (0.49) | — | |
| SCHEMBL22502109 | 0.69 | SCN4A (0.49) | — | |
| SCHEMBL366662 | 0.69 | SCN4A (0.49) | — | |
| SCHEMBL13007522 | 0.69 | NOTUM (0.32) | — | |
| SCHEMBL1516258 | 0.68 | DPP4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210155632-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2021-05-27 | — | — | US | disclosed |
| US-20180215767-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180215767-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180179218-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-06-28 | — | — | US | disclosed |
| US-20180179218-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-06-28 | — | — | US | disclosed |
| US-9828384-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | APTINYX INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20150368252-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. (US) | 2015-12-24 | — | — | US | disclosed |