Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 2/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | P2RY6 | Q15077 | 5/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17357643 | 1.00 | POLG (0.47) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL15070576 | 0.98 | POLG (0.49) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL17458663 | 0.98 | POLG (0.49) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL15074337 | 0.98 | POLG (0.49) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL17359383 | 0.98 | POLG (0.49) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL17863916 | 0.98 | POLG (0.49) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL15070639 | 0.90 | POLG (0.50) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL16374023 | 0.90 | POLG (0.50) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL17861901 | 0.90 | POLG (0.50) | POLGP2RY2POLBP2RY6P2RY4 | |
| SCHEMBL17863952 | 0.90 | POLG (0.50) | POLGP2RY2POLBP2RY6P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150366888-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366888-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NT5C3B, TYMP | POLG 956/4885P2RY2 451/4885POLB 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.