Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tilarginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 7/20 | 0.49 |
| ▸ | NOS1 known ✓ | P29475 | 7/20 | 0.49 |
| ▸ | NOS3 known ✓ | P29474 | 4/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 6/20 | 0.58 |
| ▸ | OTC | P00480 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tilarginine SCHEMBL349879 | 1.00 | DDAH1 (0.58) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL10198569 | 1.00 | DDAH1 (0.58) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL7450191 | 1.00 | DDAH1 (0.58) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL31106009 | 0.98 | DDAH1 (0.57) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL29711436 | 0.98 | DDAH1 (0.57) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL29393308 | 0.97 | DDAH1 (0.56) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL3368487 | 0.97 | DDAH1 (0.56) | DDAH1OTCNOS2NOS1NOS3 | |
| Tilarginine SCHEMBL29377396 | 0.97 | DDAH1 (0.56) | DDAH1OTCNOS2NOS1NOS3 | |
| SCHEMBL24691538 | 0.95 | DDAH1 (0.54) | DDAH1OTCNOS2NOS1NOS3 | |
| SCHEMBL30712024 | 0.89 | DDAH1 (0.47) | DDAH1NOS2NOS1NOS3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3064501-B1 | 2-METHYLSULPHANYL-6-NITRO-7-OXO-1, 2, 4-TRIAZOLO [5, 1-C][1, 2, 4]TRIAZINIDE L-ARGININE DIHYDRATE ACTIVE TOWARD WEST NILE VIRUS | LIMITED LIABILITY COMPANY URAL CENTER OF BIOPHARMACEUTICAL TECH (RU) | 2019-08-21 | — | — | EP | disclosed |
| EP-3042718-A1 | DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | Dietz, Ulrich (DE) | 2016-07-13 | — | — | EP | disclosed |
| US-20160122686-A1 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2016-05-05 | — | — | US | disclosed |
| EP-2585420-B1 | METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-9127233-B2 | Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by means of micro-or nanoemulsification | Dietz, Ulrich (DE) | 2015-09-08 | — | — | US | disclosed |
| US-8461258-B2 | Method of producing amino acid-modified organopolysiloxane emulsions | DOW CORNING TORAY COMPANY, LTD. (JP) | 2013-06-11 | — | — | US | disclosed |
| EP-2585420-A2 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | Dietz, Ulrich (DE) | 2013-05-01 | — | — | EP | disclosed |
| US-20130090488-A1 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2013-04-11 | — | — | US | disclosed |
| WO-2011160857-A2 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2011-12-29 | — | — | WO | disclosed |
| EP-2399885-A1 | Device and method for solubilizing, separating, removing and reacting carboxylic acids in aqueous or organic solutions by means of micro- or nanoemulsification | Dietz, Ulrich (DE) | 2011-12-28 | — | — | EP | disclosed |