Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | BAD | Q92934 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | ADH5 | P11766 | 1/20 | 0.52 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.51 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.51 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652706 | 0.98 | NAPRT (0.73) | NAPRTTP53TSHRMKNK1MKNK2 | |
| SCHEMBL21652691 | 0.98 | NAPRT (0.73) | NAPRTTP53TSHRMKNK1MKNK2 | |
| SCHEMBL205344 | 0.98 | NAPRT (0.73) | NAPRTTP53TSHRMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL742422 | 0.95 | NAPRT (0.70) | NAPRTTP53TSHRMKNK1MKNK2 | |
| SCHEMBL2267228 | 0.95 | NAPRT (0.70) | NAPRTTP53TSHRMKNK1MKNK2 | |
| Benzoic Acid SCHEMBL29139198 | 0.89 | NAPRT (0.67) | NAPRTTSHRMKNK1MKNK2SRD5A2 | |
| Isonicotinic Acid SCHEMBL1414914 | 0.87 | NAPRT (1.00) | NAPRTTP53TSHRLMNAMAPT | |
| Isonicotinic Acid SCHEMBL1108 | 0.87 | — | — | |
| SCHEMBL28452789 | 0.86 | NAPRT (0.57) | NAPRTTP53TSHRMKNK1MKNK2 | |
| Biphenyl SCHEMBL9847045 | 0.86 | NAPRT (0.77) | NAPRTTSHRMKNK1MKNK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960227-A1 | METHOD FOR PRODUCING METAL COMPLEX | Kuraray Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |