Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 17/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305425 | 0.86 | MDM2 (0.82) | MDM2CYP2D6CYP3A4 | |
| SCHEMBL1828449 | 0.86 | MDM2 (0.82) | MDM2CYP2D6CYP3A4 | |
| SCHEMBL1819888 | 0.81 | MDM2 (1.00) | MDM2CYP2D6CYP3A4RAF1 | |
| SCHEMBL15863686 | 0.81 | MDM2 (0.73) | MDM2CYP2D6CYP3A4TP53RAF1 | |
| SCHEMBL1819470 | 0.80 | MDM2 (1.00) | MDM2CYP2D6CYP3A4 | |
| SCHEMBL7995300 | 0.79 | MDM2 (1.00) | MDM2CYP2D6CYP3A4RAF1 | |
| SCHEMBL2457547 | 0.79 | MDM2 (1.00) | MDM2CYP2D6CYP3A4RAF1 | |
| SCHEMBL7989560 | 0.77 | MDM2 (1.00) | MDM2CYP2D6CYP3A4TP53 | |
| SCHEMBL2459937 | 0.77 | MDM2 (1.00) | MDM2CYP2D6CYP3A4TP53 | |
| SCHEMBL2455286 | 0.75 | MDM2 (0.88) | MDM2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-A1 | NEW THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2015-12-30 | — | — | EP | disclosed |