SCHEMBL17361995

SCHEMBL17361995

CNc1ccc2c(c1)CCC[C@H]2CNC(=O)OC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 14/20 0.48
DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17378765 0.87 HTR6 (0.46) HTR6
SCHEMBL316010 0.85 HTR6 (0.49) HTR6DRD2
SCHEMBL316173 0.85 HTR6 (0.49) HTR6DRD2
SCHEMBL316172 0.85 HTR6 (0.49) HTR6DRD2
SCHEMBL316011 0.85 HTR6 (0.49) HTR6DRD2
SCHEMBL17361636 0.85 HTR6 (0.49) HTR6DRD2
SCHEMBL3902907 0.85 HTR6 (0.46) HTR6DRD2
SCHEMBL3902902 0.85 HTR6 (0.46) HTR6DRD2
SCHEMBL17378845 0.83 HTR6 (0.50) HTR6
SCHEMBL17378769 0.83 KDM4C (0.44) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111909083-B Inhibitors of histone demethylase 赛尔基因昆蒂赛尔研究公司 2023-08-15 CN disclosed
EP-3160952-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2020-12-02 EP disclosed
EP-3160952-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2020-12-02 EP disclosed
EP-3741749-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-25 EP disclosed
EP-3741749-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-25 EP disclosed
EP-3738960-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-18 EP disclosed
EP-3738960-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-18 EP disclosed
CN-111909083-A Histone demethylase inhibitors 赛尔基因昆蒂赛尔研究公司 2020-11-10 CN disclosed
CN-106660982-B Histone demethylase inhibitors 赛尔基因昆蒂赛尔研究公司 2020-09-08 CN disclosed
US-10385047-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2019-08-20 US disclosed
US-9447046-B2 Histone demethylase inhibitors Celegene Quanticel Research, Inc. (US) 2016-09-20 US disclosed
US-20160107995-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-04-21 US disclosed
US-20160107995-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-04-21 US disclosed
US-20160107995-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2016-04-21 US disclosed
US-9242968-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2016-01-26 US disclosed
US-9242968-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2016-01-26 US disclosed
US-9242968-B2 Histone demethylase inhibitors Quanticel Pharmaceuticals, Inc. (US) 2016-01-26 US disclosed
US-20150376169-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-12-31 US disclosed
US-20150376169-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-12-31 US disclosed
US-20150376169-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150376169-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM6A, KDM1A HTR6 2308/4885DRD2 4714/4885
US-20160107995-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM6A, KDM1A HTR6 2308/4885DRD2 4714/4885
US-10385047-B2 Histone demethylase inhibitors KDM1B, KDM6A, KDM1A HTR6 2308/4885DRD2 4714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.