Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10941853 | 0.83 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL11656565 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL11270859 | 0.79 | TSHR (0.49) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL17365660 | 0.78 | POLB (0.63) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL17333657 | 0.78 | MEN1 (0.76) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL27436004 | 0.77 | HPGD (0.48) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL17460824 | 0.76 | TSHR (0.46) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL10223247 | 0.76 | SMN1; SMN2 (0.73) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL3483115 | 0.76 | MEN1 (0.73) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL10896138 | 0.75 | TP53 (0.43) | MEN1KMT2ASMN1; SMN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |
| US-9221821-B2 | Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds | Forest Laboratories Holdings, Limited (BM) | 2015-12-29 | — | — | US | disclosed |